منابع مشابه
Supervised normalization of microarrays
MOTIVATION A major challenge in utilizing microarray technologies to measure nucleic acid abundances is 'normalization', the goal of which is to separate biologically meaningful signal from other confounding sources of signal, often due to unavoidable technical factors. It is intuitively clear that true biological signal and confounding factors need to be simultaneously considered when performi...
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We propose two models for verbalizing numbers, a key component in speech recognition and synthesis systems. The first model uses an end-to-end recurrent neural network. The second model, drawing inspiration from the linguistics literature, uses finite-state transducers constructed with a minimal amount of training data. While both models achieve near-perfect performance, the latter model can be...
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Array-based gene expression studies frequently serve to identify genes that are expressed differently under two or more conditions. The actual analysis of the data, however, may be hampered by a number of technical and statistical problems. Possible remedies on the level of computational analysis lie in appropriate preprocessing steps, proper normalization of the data and application of statist...
متن کاملHigh-resolution spatial normalization for microarrays containing embedded technical replicates
MOTIVATION Microarray data are susceptible to a wide-range of artifacts, many of which occur on physical scales comparable to the spatial dimensions of the array. These artifacts introduce biases that are spatially correlated. The ability of current methodologies to detect and correct such biases is limited. RESULTS We introduce a new approach for analyzing spatial artifacts, termed 'conditio...
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MOTIVATION Normalization of microarray data is essential for multiple-array analyses. Several normalization protocols have been proposed based on different biological or statistical assumptions. A fundamental problem arises whether they have effectively normalized arrays. In addition, for a given array, the question arises how to choose a method to most effectively normalize the microarray data...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2010
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btq118